Sarah E. Heuer

This study shows ABCA7 deficiency in microglia disrupts lysosomal and lipid homeostasis, impairs phagocytosis, and negatively affects neuronal health in Alzheimer's disease.

This study shows that INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia, linking its dysfunction to Alzheimer's disease pathology.

The paper identifies a novel astrocyte state linked to cognitive decline in Alzheimer's disease and validates its regulators through multi-modal analysis and mechanistic experiments.

This study shows that microglia depletion in aged mice increases optic nerve damage in glaucoma models, suggesting microglia protect against ocular hypertension-induced retinal ganglion cell loss.

This study examines the effects of 2-deoxyglucose on gene expression across nine tissues in mice, identifying tissue-specific changes in metabolic and immunological pathways.

The paper investigates age-related synaptic changes in two mouse strains, finding differential synaptic loss and efficiency in specific circuits, suggesting genetic factors influence cognitive decline resistance.

The paper shows genetic context influences microglia-synaptic interactions in AD mouse models, with differential effects in B6 and PWK strains.