Annabel J. Curle

BCOR mutations establish a persistent culture-adaptive state in human induced pluripotent stem cells

This study identifies BCOR mutations in hiPSCs as a culture-adaptive state causing chromatin, transcriptomic, and proteomic changes, and develops a qPCR assay for detection.

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease

The paper investigates TE transcription in Parkinson's disease brains, finding region- and cell-type-specific TE activation linked to an interferon response in microglia and neurons.

INPP5D/SHIP1 regulates endo-lysosome function and cargo-selective phagocytosis in human microglia

This study shows that INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia, linking its dysfunction to Alzheimer's disease pathology.

Hallmarks and metabolic regulation of type 2 activated human lung macrophages

This study identifies hallmark gene expression and metabolic profiles of type 2 activated human lung macrophages using primary tissue-derived cells.

The immunological profile of RC17 hESC-derived dopaminergic neural progenitor cells in vitro: implications for the STEM-PD clinical trial.

The paper assesses the immunogenicity of RC17 hESC-derived dopaminergic neural progenitor cells, finding they are immunosuppressive and similar to fetal tissue, suggesting reduced need for aggressive immunosuppression post-transplantation.