Jean Paul Chadarevian

This study shows that transplanting wild-type human iPSC-derived microglia into progranulin-deficient mice reduces neuropathology, circuit dysfunction, and behavioral issues in a FTD model.

This study shows that APOE4 impairs lipoprotein secretion in microglia, leading to lysosomal and mitochondrial dysfunction and a proinflammatory phenotype.

This study shows that INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia, linking its dysfunction to Alzheimer's disease pathology.

The paper identifies a microglia population that takes up circulatory proteins, enhancing phagocytosis and innate immunity through ApoA-I uptake.

This study shows that ER and SOCE Ca2+ signals are not required for directed migration of human microglia in response to purinergic stimuli, suggesting a Ca2+-independent mechanism involving cyclic AMP.

This study shows that TREM2 loss in human iPSC-derived microglia leads to altered Ca2+ signaling and motility via purinergic receptor pathways.