Author

Gizem Terzioğlu

Brigham and Women's HospitalORCID 0000-0003-4735-6322Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:differential expression· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Assay:proteomics· 3 Research Focus:cell-cell communication· 2 Approach:statistical model· 2

Frequent Co-Authors

Nicholas T. SeyfriediD· 4 shared Philip L. De JageriD· 4 shared Tracy L. Young‐PearseiD· 4 shared Courtney R. BenoitiD· 2 shared David A. Bennett· 2 shared Duc Minh DuongiD· 2 shared Fasih M. AhsaniD· 2 shared Garrett M. FogoiD· 2 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersNeuroscience

Nicholas T. SeyfriedORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 19, 2026

The Alzheimer's disease risk gene ABCA7 regulates microglial lysosomal and lipid homeostasis and promotes phagocytosis to maintain neuronal health

Sarah E. Heuer, Fasih M. Ahsan, Gizem Terzioğlu…·Tracy L Young-Pearse

This study shows ABCA7 deficiency in microglia disrupts lysosomal and lipid homeostasis, impairs phagocytosis, and negatively affects neuronal health in Alzheimer's disease.

DOI 10.64898/2026.10.16.759681

humanproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintOct 27, 2025

INPP5D/SHIP1 regulates endo-lysosome function and cargo-selective phagocytosis in human microglia

Gizem Terzioğlu, Emma S. Karp, Sarah E. Heuer…·Tracy L. Young‐Pearse

This study shows that INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia, linking its dysfunction to Alzheimer's disease pathology.

4 citations

humanproteomics

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NeurosciencebioRxivPreprintSep 20, 2025

BAG3 coordinates astrocytic proteostasis of Alzheimer's disease-linked proteins via proteasome, autophagy, and retromer complex interactions

Zachary M. Augur, Garrett M. Fogo, Courtney R. Benoit…·Tracy L. Young‐Pearse

This study identifies BAG3's role in astrocytic proteostasis in Alzheimer's disease by showing its interactions with autophagy, proteasome, and retromer components, and its impact on Aβ clearance.

2 citations

humanscRNA-seq

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NeurosciencebioRxivPreprintMar 31, 2025

A proteogenomic tool uncovers protein markers for human microglial states

Verena Claudia Haage, Alex R. Bautista, John F. Tuddenham…·Philip L. De Jager

The paper introduces a proteomic tool to identify protein markers for human microglial states and validates their utility in purification and differentiation.

2 citations

humanCITE-seq

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NeuroscienceGliaPeer-reviewedFeb 3, 2025

Contributions of genetic variation in astrocytes to cell and molecular mechanisms of risk and resilience to late onset Alzheimer's disease

Hyo Lee, Richard V. Pearse, Alexandra M Lish…·Tracy L. Young‐Pearse

The paper uses iPSC-derived astrocytes to study genetic risk factors for Alzheimer's disease, finding concordant molecular changes in both astrocytes and brain tissue.

22 citationstop 1%

humanbulk RNA-seq

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