Fasih M. Ahsan

This study shows ABCA7 deficiency in microglia disrupts lysosomal and lipid homeostasis, impairs phagocytosis, and negatively affects neuronal health in Alzheimer's disease.

The paper identifies reductive stress as a toxicity of biguanides like metformin, showing that fatty acid biosynthesis protects against this effect and could be targeted in cancer.

This study identifies that impaired ribosomal RNA biogenesis enhances resistance to reductive stress in C. elegans by reducing NADPH/NADH accumulation and GSH levels.

This study shows that INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia, linking its dysfunction to Alzheimer's disease pathology.

This study shows that AMPK regulates NPP-16/NUP50 to enhance lipid catabolism and extend C. elegans lifespan, independent of its nuclear transport function.

This study identifies H3K27ac as a key transcriptional switch that promotes longevity by enhancing lipid catabolism and antioxidant defenses under hormetic nutrient stress in C. elegans.

This study shows phenformin extends lifespan in C. elegans more consistently than metformin, which is affected by environmental factors like agar batch.

This study identifies ether lipid biosynthesis as a key pathway mediating the longevity benefits of biguanides like metformin in C. elegans.

The paper shows that TORC2 deficiency in C. elegans slows development through the Hh/Patched signaling pathway and the transcription factor pqm-1.

This study shows that riboflavin depletion in C. elegans extends lifespan and improves metabolic health through multiple pathways.