Identification of pre-existing microbiome and metabolic vulnerabilities to escalation of oxycodone self-administration and identification of a causal role of short-chain fatty acids in addiction-like behaviors.
Sierra Simpson, Adam Kimbrough, Gregory Peters, Emma Wellmeyer, Rio Mclellan, Natalie Walker, Haoyu Jia, Sharon Hu, Mohini R. Iyer, Varshini Sathish, Sharona Sedighim, Marsida Kallupi, Molly Brennan, Lisa Maturin, Talyn E. Hughes, , Olivier George
The paper identifies microbiome and metabolic vulnerabilities linked to oxycodone self-administration escalation and shows SCFAs have a causal role in addiction-like behaviors.
bioRxiv · Jul 23, 2022 · PreprintNeuroscience