Adam Kimbrough

This study performs a GWAS on cocaine self-administration in rats, identifying six genome-wide significant loci, including one linked to carboxylesterase genes involved in cocaine metabolism.

This study shows that inhibiting the cortical amygdala reduces alcohol intake in dependent mice and restores thalamic connectivity during withdrawal.

This study develops a mouse model of fentanyl self-administration and withdrawal, showing escalation in intake, withdrawal symptoms, and prolonged craving.

The paper shows that escalation of cocaine intake, progressive ratio responding, and continued use despite adverse consequences are highly correlated in rats, with sex differences in addiction-like behaviors.

This study identifies sex differences in neural network reorganization following frontloaded binge alcohol drinking in mice using functional connectivity analysis.

This study examines how visual experience affects inter-areal network connectivity in the visual cortex of Fmr1 KO mice, revealing impaired synchronization and synaptic connectivity in FX models.

The paper investigates how cholinergic systems contribute to changes in brain functional connectivity during nicotine withdrawal in male mice, identifying two distinct long-range cholinergic networks and associated genes.

This study compares voluntary and forced ethanol exposure in rats, finding similar drinking escalation and blood alcohol levels but distinct brain region activation during withdrawal.

The paper identifies individual differences in oxycodone addiction-like behaviors in HS rats to uncover genetic factors contributing to vulnerability and resilience.

The paper identifies microbiome and metabolic vulnerabilities linked to oxycodone self-administration escalation and shows SCFAs have a causal role in addiction-like behaviors.

The paper uses single-cell whole-brain imaging to analyze how psychostimulant withdrawal alters brain functional architecture, finding reduced modularity as a common feature across drugs.

This study demonstrates that 48 hours of conditioned flavor exposure in rats leads to a long-lasting flavor preference that persists for at least 48 days.

The paper validates the three-stage theory of addiction using single-cell whole-brain imaging in a mouse model, showing abstinence reduces brain modularity and clusters regions corresponding to each stage.

The paper examines nuclear TORC1 localization and its co-localization with c-Fos in the visceral neuraxis after LiCl injection, finding that TORC1 is not necessarily required for c-Fos induction.

This study examines irritability-like behavior in ethanol-dependent rats and shows that CRF1 receptor antagonism reduces this behavior during abstinence.

This study shows that functional knockout of forebrain 14-3-3 disrupts conditioned taste aversion learning, leading to rapid extinction or failure to reconsolidate.