Giordano de Guglielmo

The paper uses Genomic SEM to identify loci underlying locomotor activity in rats, finding 31 loci compared to fewer from other methods.

This study performs a GWAS on cocaine self-administration in rats, identifying six genome-wide significant loci, including one linked to carboxylesterase genes involved in cocaine metabolism.

This study shows that higher addiction-like severity in rats predicts prolonged oxycodone withdrawal-induced allodynia, with stronger associations between self-administration behaviors and pain sensitivity.

This study shows ivermectin reduces alcohol intake during withdrawal by enhancing GABAergic inhibition in the CeA, specifically in rats with high P2rx4 expression.

The paper establishes an Alcohol BioBank using genetically diverse HS rats to study AUD, providing samples for genomic, transcriptomic, and proteomic analyses.

This study shows that perinatal fentanyl exposure in rats leads to long-term addiction risk and central amygdala gene dysregulation, providing insights into the molecular mechanisms of NOWS and its consequences.

The paper identifies circRNA hypomethylation in the human amygdala linked to FKBP5 in alcohol use disorder, with replication in an animal model.

This study finds that irregular estrous cycles in HS rats are associated with severe cocaine addiction-like behaviors, but estrous phase itself does not influence cocaine self-administration.

The paper shows that escalation of cocaine intake, progressive ratio responding, and continued use despite adverse consequences are highly correlated in rats, with sex differences in addiction-like behaviors.

The paper genotypes Y and mitochondrial chromosomes in heterogeneous stock rats and finds no significant associations with complex traits, except for gene expression on these chromosomes.

This study compares voluntary and forced ethanol exposure in rats, finding similar drinking escalation and blood alcohol levels but distinct brain region activation during withdrawal.

The paper identifies cell type-specific gene regulatory changes in the amygdala of rats with varying cocaine addiction-like behaviors, linking them to energy metabolism, GABAergic inhibition, and chromatin accessibility.

This study shows that Reelin deficiency increases cocaine-induced hyperlocomotion in mice by enhancing neuronal activity in the dorsomedial striatum, without affecting cocaine reward.

The paper identifies individual differences in oxycodone addiction-like behaviors in HS rats to uncover genetic factors contributing to vulnerability and resilience.

The paper identifies microbiome and metabolic vulnerabilities linked to oxycodone self-administration escalation and shows SCFAs have a causal role in addiction-like behaviors.

The paper tests individual differences in response to methadone, buprenorphine, and naltrexone in rats with opioid use disorder, finding varying efficacy based on addiction severity.

The paper investigates how drug exposure alters gene regulatory networks in the brain using multi-omics approaches, identifying enhancer repression and transcription factor involvement in addiction-related behaviors.

This study investigates the effects of deep brain stimulation (DBS) on cocaine self-administration in cocaine-dependent rats and finds it increases cocaine intake but raises GluR1 levels in the central nucleus of the amygdala.

The paper examines individual differences in addiction-like behaviors and cocaine versus food choice in Heterogeneous Stock rats, finding that high addiction score rats show increased cocaine preference after recent cocaine use.

Vaping nicotine-containing e-cigarettes causes addiction-like behaviors and cardiopulmonary issues in rats, which are reduced by varenicline.

This study shows that inhibiting glyoxalase 1 with pBBG reduces alcohol self-administration in both dependent and nondependent rats, with greater effect in dependent animals.

This study examines irritability-like behavior in ethanol-dependent rats and shows that CRF1 receptor antagonism reduces this behavior during abstinence.

Cebranopadol reduces cocaine intake escalation and reinstatement in rats but induces conditioned place preference.

This study identifies CeA CRF neurons and their projections to the BNST as drivers of excessive alcohol drinking and withdrawal in rats.