Phospholipase D3 regulates lysosomal morphology, biogenesis, and function in neurons.
Yongchao Wang, Cristian Carvajal‐Tapia, Stuti Jain, Emmeline Wang, Paige Rieschick, Nathaniel L. Hepowit, Nathan Appelbaum, Alex Prusky, Theodora Anghelina, Avelyn Kulsomphob, Vaibhav A. Janve, Samuel J. Frank, Alena Shostak, Timothy J. Hohman, Bret C. Mobley, , Matthew Schrag
This study shows PLD3 regulates lysosomal morphology, biogenesis, and function in neurons by affecting protein abundance, subcellular location, and clearance of aggregated proteins.
bioRxiv · Sep 26, 2024 · PreprintCell Biology