Nathaniel L. Hepowit

Methionine-triggered growth arrest reveals activation of Gcn2 by methionine transporter endocytosis

The paper shows that excess methionine triggers growth arrest via Gcn2 activation, which depends on methionine transporter endocytosis.

Sphingolipid metabolism drives mitochondria remodeling during aging and oxidative stress

This study shows that sphingolipid metabolism influences mitochondrial morphology changes in aging yeast cells and during oxidative stress.

Phospholipase D3 regulates lysosomal morphology, biogenesis, and function in neurons.

This study shows PLD3 regulates lysosomal morphology, biogenesis, and function in neurons by affecting protein abundance, subcellular location, and clearance of aggregated proteins.

ER-phagy drives age-onset remodeling of endoplasmic reticulum structure-function and lifespan

This study shows that ER-phagy drives age-related ER remodeling and lifespan, revealing it as a protective mechanism in aging.

Reduced sphingolipid biosynthesis modulates proteostasis networks to enhance longevity

This study investigates how myriocin, a sphingolipid biosynthesis inhibitor, enhances longevity by modulating ubiquitination and proteostasis networks in yeast.