Enno Hartmann

Sec61 translocon inhibitor Flavitransin blocks selectively dengue virus polyprotein insertion into the ER membrane with pan-flavivirus antiviral potency

Flavitransin inhibits dengue virus polyprotein insertion into the ER membrane, showing broad antiviral activity against flaviviruses.

Normal male fertility in a mouse model of KPNA2 deficiency

This study investigates KPNA2's role in male fertility using KPNA2-deficient mice, finding reduced sperm count but no infertility.

Karyopherin α2 is a maternal effect gene required for early embryonic development and female fertility in mice

This study shows that KPNA2 deficiency in mice causes embryonic arrest at the 2-cell stage and disrupts genome activation and nuclear translocation of Nucleoplasmin 2.

Importin α7 deficiency causes infertility in male mice by disrupting spermatogenesis

This study shows that importin α7 deficiency in male mice causes infertility by disrupting spermatogenesis through impaired Sertoli cell function and defects in spermiogenesis.