Volkhard Helms

Predicting Differential Protein-Protein Interactions

The paper develops a random forest model to predict differential protein-protein interactions between experimental conditions using MINT embeddings and mass spectrometry data.

Stress induces DCP2 translation via a stalling-dependent mechanism

The paper identifies DCP2 as an ISR-induced transcript whose translation is regulated by an overlapping ORF that acts as an inhibitory element, which is relieved during stress.

Mammalian MemPrep establishes the lipid composition of ER membranes in HEK293T cells

This study characterizes the lipid composition of mammalian ER membranes using MemPrep, showing a common lipid profile across ER subdomains and linking lipid and protein biophysical properties.

Sec61 translocon inhibitor Flavitransin blocks selectively dengue virus polyprotein insertion into the ER membrane with pan-flavivirus antiviral potency

Flavitransin inhibits dengue virus polyprotein insertion into the ER membrane, showing broad antiviral activity against flaviviruses.

Melanocyte differentiation and mechanosensation are differentially modulated by distinct extracellular matrix proteins

This study investigates how different extracellular matrix proteins and substrate stiffness affect melanocyte differentiation and mechanosensation, revealing context-dependent MITF regulation.

Engineering Material Properties of Transcription Factor Condensates to Control Gene Expression in Mammalian Cells and Mice

This study tunes the material properties of transcription factor condensates to show their impact on gene expression levels in mammalian cells and mice.

Deregulation of epigenetic marks is correlated to differential exon usage of developmental genes

The paper connects differential exon usage in developmental stages to changes in histone marks at exon boundaries across 19 human tissues and cultured cells.