Maarten Jacquemyn

Flavitransin inhibits dengue virus polyprotein insertion into the ER membrane, showing broad antiviral activity against flaviviruses.

This paper reveals that SINE compounds induce XPO1 degradation via an allosteric mechanism involving ASB8, distinct from molecular glue degraders.

This study identifies mutations in influenza hemagglutinin that increase acid-stability and decrease cleavability, with implications for viral transmissibility and vaccine development.

This paper identifies EPB-113, a guanidine-based inhibitor of coronavirus nsp15 endoribonuclease, which suppresses viral replication and selects for interferon-susceptible mutants.