Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures
Laura Tapella, Giulia Dematteis, Federico Alessandro Ruffinatti, Luisa Ponzoni, Fabio Fiordaliso, Alessandro Corbelli, Enrico Albanese, Beatrice Pistolato, Jessica Pagano, Elettra Barberis, Emílio Marengo, Claudia Balducci, Gianluigi Forloni, Chiara Verpelli, Carlo Sala, , Dmitry Lim
This study shows that deleting calcineurin in astrocytes leads to proteome changes resembling Alzheimer's and epilepsy, and increases seizure risk in mice.
Cell Calcium · Sep 27, 2021Peer-reviewedNeuroscience