Gianluigi Forloni

This paper develops a harmonized MRI QC framework using phantoms to identify sources of variability across field strengths and sites, showing that field strength alone does not fully characterize MRI performance.

The paper demonstrates that glycan-coated nanoparticles can sequester complement lectin pathway components, reducing ischemic brain injury in a mouse model.

This study investigates the role of SUMO2/3 modification in mitigating Tau-induced synaptic and cognitive dysfunction in disease models.

This study shows that deleting calcineurin in astrocytes leads to proteome changes resembling Alzheimer's and epilepsy, and increases seizure risk in mice.

This study shows that defective cyclophilin A (PPIA) leads to TDP-43 proteinopathy, contributing to ALS and FTD by disrupting TDP-43 function and causing neurodegeneration.

The paper develops a polygenic predictor for treatment-resistant depression using whole exome sequencing and genome-wide genotyping, finding that genetic scores combined with clinical factors improve prediction.

The paper identifies a genetic variant near CXCR4 associated with increased risk for PSP and PD, showing dysregulation of CXCR4 and microglia-related genes in neurodegenerative diseases.