Federico Alessandro Ruffinatti

The Pervasive Negative Regulation of Ion Channel Functional Families Across Human Cancers

The paper identifies a conserved downregulation of ion channels and upregulation of specific pumps across 19 cancer types using gene set enrichment analysis.

Profiling the Expression of Transportome Genes in cancer: A systematic approach

The paper introduces a database and pipeline to analyze transportome dysregulation in cancer, finding shared dysregulation patterns across cancer types.

BioTEA: containerized methods of analysis for microarray-based transcriptomics data

BioTEA is a containerized R/Bioconductor-based tool for differential expression analysis of microarray data, offering reproducibility and flexibility through customizable pipelines.

Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures

This study shows that deleting calcineurin in astrocytes leads to proteome changes resembling Alzheimer's and epilepsy, and increases seizure risk in mice.

Deletion of calcineurin from GFAP-expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na+/K+ ATPase.

This study shows that deleting calcineurin in astrocytes impairs neuronal excitability in the cerebellum and hippocampus by reducing Na+/K+-ATPase activity.