G6PC2 controls glucagon secretion by defining the setpoint for glucose in pancreatic α-cells
Varun Bahl, Eric Waite, Reut Rifkind, Zenab Hamdan, Catherine Lee May, Elisabetta Manduchi, Benjamin F. Voight, Michelle Y. Y. Lee, Mark Tigue, Nicholas Manuto, Benjamin Gläser, Dana Avrahami, Klaus H. Kaestner
This study identifies G6PC2's role in regulating glucagon secretion in α-cells, showing it controls glucose setpoint and suggests G6PC2 inhibitors could improve glycemic control.
Science Translational Medicine · Jan 1, 2025Peer-reviewedGenetics