Author

Catherine Lee May

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetics· 4 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Klaus H. KaestneriD· 5 shared Ali NajiiD· 2 shared Ashleigh R. Morgan· 2 shared Dan Lichtental· 2 shared Dana AvrahamiiD· 2 shared Emmanuel SkordalakesiD· 2 shared Maria L. GolsoniD· 2 shared Mark Tigue· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersGenetics

Klaus H. KaestnerORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1

Riham Smoom, Catherine Lee May, Dan Lichtental, Kamil Bar-Ness, Reina Rangel, Johad Khoury, Daphna Nachmani, Dana Avrahami, Farida Ahangari, Emmanuel Skordalakes, Naftali Kaminski, Klaus H. Kaestner, Yehuda Tzfati

This study introduces two RTEL1 mouse models with distinct mutations at amino acid 492, showing that M492K affects telomere length while M492I impairs telomere protection, leading to different disease phenotypes.

Nucleic Acids Research · May 29, 2025Peer-reviewedGenetics

G6PC2 controls glucagon secretion by defining the setpoint for glucose in pancreatic α-cells

Varun Bahl, Eric Waite, Reut Rifkind, Zenab Hamdan, Catherine Lee May, Elisabetta Manduchi, Benjamin F. Voight, Michelle Y. Y. Lee, Mark Tigue, Nicholas Manuto, Benjamin Gläser, Dana Avrahami, Klaus H. Kaestner

This study identifies G6PC2's role in regulating glucagon secretion in α-cells, showing it controls glucose setpoint and suggests G6PC2 inhibitors could improve glycemic control.

Science Translational Medicine · Jan 1, 2025Peer-reviewedGenetics

Telomouse - a mouse model with human-length telomeres generated by a single amino acid change in RTEL1

Riham Smoom, Catherine Lee May, Vivian Ortiz, Mark Tigue, Hannah M. Kolev, Melissa M. Rowe, Yitzhak Reizel, Ashleigh R. Morgan, Nachshon Egyes, Dan Lichtental, Emmanuel Skordalakes, Klaus H. Kaestner, Yehuda Tzfati

This paper introduces a mouse model with human-length telomeres by modifying RTEL1 and shows its impact on regenerative capacity.

Nature Communications · Oct 23, 2023Peer-reviewedGenetics

The three-dimensional chromatin structure of the major human pancreatic cell types reveals lineage-specific regulatory architecture of T2D risk

Chun Su, Long Gao, Catherine Lee May, James A. Pippin, Keith D. Boehm, Michelle Lee, Chengyang Liu, Matthew C. Pahl, Maria L. Golson, Ali Naji, Struan F.A. Grant, Andrew D. Wells, Klaus H. Kaestner

The paper uses 3D chromatin maps to identify cell-type-specific regulatory architecture of type 2 diabetes risk by analyzing pancreatic cell types.

bioRxiv · Nov 30, 2021 · PreprintGenetics

Multiomics single-cell analysis of human pancreatic islets reveals novel cellular states in health and type 1 diabetes

Maria Fasolino, Gregory W. Schwartz, Maria L. Golson, Yue Julia Wang, Ashleigh R. Morgan, Chengyang Liu, Jonathan Schug, Jinping Liu, Minghui Wu, Daniel Traum, Ayano Kondo, Catherine Lee May, Naomi Goldman, Wenliang Wang, Michael D. Feldman, , Golnaz Vahedi

bioRxiv · Jan 28, 2021 · PreprintGenomics