ZNF423 depletion induces the integrated stress response and represents a potential vulnerability in NF1-associated MPNST
Sarah K. Morrow, Christine A. Berryhill, Emily E. White, Colin J Beach, Shelley A.H. Dixon, Emily Y. Zhang, Christopher M. Davis, Erin Mannion, Brooke E. Hickey, Henry Elmer Mang, Marisa D. Ciesielski, Silpa Gampala, Mohammad Reza Saadatzadeh, Emmanuel A Gyabaah, Christopher D. Collier, , Steven P. Angus
This study shows ZNF423 depletion triggers the integrated stress response and sensitizes NF1-associated MPNST to chemotherapy, identifying it as a potential therapeutic target.
bioRxiv · Mar 5, 2026 · PreprintCancer Biology