This study shows that genetic activation of ERK2 in mice models key neurodevelopmental features of Rasopathy syndromes, including cognitive impairments and facial dysmorphology.

Human Genetics and Genomics Advances · May 1, 2026Peer-reviewedGenetics

Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease Models

Cynthia D. Jesudason, Claudia Rangel‐Barajas, Colin J Beach, Daniel E. Beck, Isaac Caballero-Floran, Brent Clayton, Lais Da Silva, Juliane C David, Suzanne Doolen, Alexandra N. Faulkner, Adam K. Hamdani, Hasi Huhe, Kevin Huynh, Ryan D. Imhoff, June Javens‐Wolfe, , Timothy I. Richardson

This study identifies SHIP1 ligands with brain exposure and in vivo activity in Alzheimer's models, showing target engagement and reduced neuroinflammation.

Journal of Medicinal Chemistry · Apr 30, 2026Peer-reviewedPharmacology & Toxicology

ZNF423 depletion induces the integrated stress response and represents a potential vulnerability in NF1-associated MPNST

Sarah K. Morrow, Christine A. Berryhill, Emily E. White, Colin J Beach, Shelley A.H. Dixon, Emily Y. Zhang, Christopher M. Davis, Erin Mannion, Brooke E. Hickey, Henry Elmer Mang, Marisa D. Ciesielski, Silpa Gampala, Mohammad Reza Saadatzadeh, Emmanuel A Gyabaah, Christopher D. Collier, , Steven P. Angus

This study shows ZNF423 depletion triggers the integrated stress response and sensitizes NF1-associated MPNST to chemotherapy, identifying it as a potential therapeutic target.

bioRxiv · Mar 5, 2026 · PreprintCancer Biology

RIPK1 regulates beta-cell fate via actions on gene expression and kinase signaling in a mouse model of beta-cell self-reactivity

Christopher Contreras, Noyonika Mukherjee, Arianna Harris-Kawano, Egan G. Mather, Nansalmaa Amarsaikhan, Christopher M. Davis, Christine A. Berryhill, Madeline Peyton, Debjyoti Kundu, Kaitlyn A. Colglazier, Addison S. Miller, Renato Chaves Souto Branco, Travis S. Johnson, Steven P. Angus, Sylvaine You, , Andrew T. Templin

This study shows RIPK1 promotes beta-cell death in autoimmune diabetes by affecting gene expression and kinase signaling, suggesting it as a therapeutic target.

Cell Death and Disease · Feb 12, 2026Peer-reviewedCell Biology

Chemical inhibition of a bacterial immune system

Zhiyu Zang, Olivia K. Duncan, Dziugas Sabonis, Iana Fedorova, Yun Shi, Gause Miraj, Shuai Le, Jun Deng, Yuhao Zhu, Yanyao Cai, Chengqian Zhang, Garima Arya, Shelley A.H. Dixon, Steven P. Angus, Breck A. Duerkop, , Joseph P. Gerdt

This study identifies chemical inhibitors that block a bacterial immune system, enhancing phage therapy efficacy against resistant strains.

Cell Host & Microbe · Jan 30, 2026Peer-reviewedBiochemistry

A novel induced pluripotent stem cell model of schwann cell differentiation reveals NF2-related gene regulatory networks of the extracellular matrix

Olivia Lazaro, Sihong Li, William Carter, Oluwamayowa Awosika, Sylvia Robertson, Brooke E. Hickey, Steven P. Angus, Austin House, D. Wade Clapp, Abdul S. Qadir, Travis S. Johnson, Steven D. Rhodes

The paper develops a hiPSC model of Schwann cell differentiation and identifies gene regulatory networks related to NF2 and extracellular matrix organization.

bioRxiv · May 2, 2024 · PreprintBioinformatics