Silpa Gampala

This paper uses integrated PTM proteomics to show that Ref-1 inhibition rapidly remodels redox and mitochondrial signaling in pancreatic cancer cells.

This paper identifies PRMT5 as a therapeutic target in MTAP-deficient MPNSTs, showing that its inhibition suppresses cell growth and enhances DNA damage when combined with chemotherapy.

This study shows ZNF423 depletion triggers the integrated stress response and sensitizes NF1-associated MPNST to chemotherapy, identifying it as a potential therapeutic target.

This paper introduces scFEA, a graph neural network model to estimate cell-wise metabolic flux from scRNA-seq data, validated with matched metabolomics data and applied to multiple datasets.