Author

Mohammad Reza Saadatzadeh

Indiana University IndianapolisORCID 0000-0002-7976-7970Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Christopher D. CollieriD· 2 shared Karen E. PollokiD· 2 shared Aaron Cohen‐GadoliD· 1 shared Alyssa L. WalkeriD· 1 shared Brooke E. HickeyiD· 1 shared Christine A. BerryhilliD· 1 shared Christine A. PratilasiD· 1 shared Christopher M. DavisiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Christopher D. CollierORCID

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2 papers

Recent·Most cited

ZNF423 depletion induces the integrated stress response and represents a potential vulnerability in NF1-associated MPNST

Sarah K. Morrow, Christine A. Berryhill, Emily E. White, Colin J Beach, Shelley A.H. Dixon, Emily Y. Zhang, Christopher M. Davis, Erin Mannion, Brooke E. Hickey, Henry Elmer Mang, Marisa D. Ciesielski, Silpa Gampala, Mohammad Reza Saadatzadeh, Emmanuel A Gyabaah, Christopher D. Collier, , Steven P. Angus

This study shows ZNF423 depletion triggers the integrated stress response and sensitizes NF1-associated MPNST to chemotherapy, identifying it as a potential therapeutic target.

bioRxiv · Mar 5, 2026 · PreprintCancer Biology

Repurposing Romidepsin for Osteosarcoma: Screening FDA-Approved Oncology Drugs with Three-Dimensional Osteosarcoma Spheroids

Emily E. Seiden, Spencer M. Richardson, Leah A. Everitt, Gabrielle J. Knafler, Gavin P. Kinsella, Alyssa L. Walker, Venetia A. Whiteside, James D. Buschbach, Deep A. Gandhi, Mohammad Reza Saadatzadeh, L. Daniel Wurtz, Patrick J. Getty, Sheldon L. Padgett, Rance M. Gamblin, Michael O. Childress, , Edward M. Greenfield

This paper identifies romidepsin as a promising repurposed drug for osteosarcoma using 3D spheroid models, showing efficacy against metastatic cells and outperforming other HDIs.

bioRxiv · May 22, 2025 · PreprintCancer Biology