STI1 domain dynamically engages transient helices in disordered regions to drive self-association and phase separation of yeast ubiquilin Dsk2
Nirbhik Acharya, Emily A. Daniel, Thuy Phuong Dao, Jessica K. Niblo, Erin Mulvey, Shahar Sukenik, Daniel Adam Kraut, Jeroen Roelofs, Carlos A. Castañeda
This study identifies the STI1 domain's role in driving Dsk2 self-association and phase separation through interactions with transient helices in disordered regions, with implications for proteasome condensate formation.
bioRxiv · Mar 14, 2025 · PreprintBiochemistry