Nirbhik Acharya

Tubulin C-terminal tails are pH sensors that regulate microtubule function

The paper investigates how tubulin C-terminal tails respond to pH changes and shows their role in regulating microtubule interactions through protonation of glutamate residues.

Intramolecular interactions between folded and disordered regions shape ubiquilin structure and function

The paper investigates how intramolecular interactions between folded and disordered regions of ubiquilin proteins influence their structure and function across different species.

DNA branch migration across intact membranes powers an inside-out GPCR analog for lysis-free detection of intracellular RNA with on-membrane amplification

This paper demonstrates DNA branch migration across lipid membranes to detect intracellular RNA without lysing cells, using a synthetic GPCR-like system called HALOS.

STI1 domain dynamically engages transient helices in disordered regions to drive self-association and phase separation of yeast ubiquilin Dsk2

This study identifies the STI1 domain's role in driving Dsk2 self-association and phase separation through interactions with transient helices in disordered regions, with implications for proteasome condensate formation.