IL-33 promotes transcriptional and metabolic adaptations of tissue-resident Th2 cells
Anna K. Kania, David E. Sanin, Xinyue Gu, Mia Gidley, Eryk Kokosinski, Allen D. Smith, Erika L. Pearce, Edward J Pearce
This study shows IL-33 promotes the development of tissue-resident-like Th2 cells through arginine metabolism and mTORC1 activation, with transcriptional changes linked to tissue integration.
The Journal of Immunology · Apr 1, 2026Peer-reviewedImmunology