Edward J. Pearce

This study shows antigen-presenting cancer-associated fibroblasts (apCAFs) in murine pancreatic tumors influence regulatory T cell phenotype and function through CXCL9 and CCL22, affecting immune checkpoint blockade response.

This study shows IL-33 promotes the development of tissue-resident-like Th2 cells through arginine metabolism and mTORC1 activation, with transcriptional changes linked to tissue integration.

This study shows that monocyte behaviors can predict aging and frailty in humans using single-cell analysis and a deep learning model.