Erika L. Pearce

This study shows IL-33 promotes the development of tissue-resident-like Th2 cells through arginine metabolism and mTORC1 activation, with transcriptional changes linked to tissue integration.

The paper shows that cysteine in CD8+ T cells is partitioned into glutathione and FeS-cluster synthesis, supporting effector functions and proliferation, respectively.

This study investigates the role of ATP citrate lyase (ACLY) in cardiac function and NAD+/NADH balance, finding it is reduced in heart failure and its inhibition impairs cardiac function and metabolism.

The paper introduces Compass, an algorithm that uses single-cell RNA-Seq and flux balance analysis to characterize metabolic states in Th17 cells, revealing a metabolic switch and novel anti-inflammatory regulators.