Sphingosine-1-phosphate cross-talks to Notch via a S1PR1-Dll4-MPDZ complex to regulate endothelial barrier function
Jennifer Bays, Jessica L. Teo, Freddy Suarez Rodriguez, Alanna M. Farrell, Amy E. Stoddard, Esther Koh, Timothy Hla, Christopher S. Chen
This study identifies a novel S1PR1-Dll4-MPDZ-Notch1 signaling pathway that enhances endothelial barrier integrity through Notch activation and Rac1 activity.
bioRxiv · May 21, 2026 · PreprintCell Biology