Timothy Hla

This study shows that S1PR1 signaling in neutrophils enhances their survival and reduces inflammation but impairs bacterial clearance and protects against lung injury in viral infections.

This study identifies a novel S1PR1-Dll4-MPDZ-Notch1 signaling pathway that enhances endothelial barrier integrity through Notch activation and Rac1 activity.

This study identifies SPHK1 as a key driver of SMC hyperproliferation in elastin deficiency, showing its role in both pathological and physiological arterial remodeling.

This study shows that endothelial-derived sphingolipids are essential for vascular development and systemic lipid homeostasis, with effects on retinal vascularization and liver toxicity.

This study identifies S1PR1 as a regulator of lymphatic vessel quiescence by inhibiting LSS-dependent VEGF-C signaling in lymphatic endothelial cells.

The paper characterizes S1PR1-regulated transcriptomes in aortic endothelial cells, revealing distinct subtypes and signaling mechanisms in arterial and lymphatic endothelium.