A single cell trajectory of human archetypal pluripotent stem cell differentiation to trophoblast stem cells reveals induction of endogenous BMP5/7 and GATA3 without transitioning through a naive state
Ethan Tietze, Amilton de Lima Barbosa, Bruno Henrique Silva Araújo, Veronica Luiza Vale Euclydes, Hyeon Jin Cho, Yong Kyu Lee, Arthur Sant’Anna Feltrin, Bailey Spiegelberg, Alan P. R. Lorenzetti, Joyce van de Leemput, Pasquale Di Carlo, Tomoyo Sawada, Gianluca Ursini, Kynon JM Benjamin, Helena Brentani, , Jennifer A. Erwin
This paper shows that primed human pluripotent stem cells can differentiate to trophoblast stem cells without becoming naive, using specific signaling conditions and revealing a transcriptional network involving BMP5/7 and GATA3.
bioRxiv · Aug 29, 2020 · PreprintDevelopmental Biology