Gianluca Ursini

Image-Based Profiling of Induced Trophoblast Stem Cells Identifies Signatures Associated with Sex, Schizophrenia Genomic Risk and Placental Stress

The paper uses image-based profiling of hiPSC-derived trophoblasts to identify SCZ risk signatures linked to sex, placental genomic risk, and hypoxic stress.

Genetic Architecture of Placental Efficiency for Term Infants: Evidence from Monoaminergic Pathways and Placental Tissue Expression in the Norwegian Mother, Father and Child Cohort Study (MoBa)

The paper conducts a GWAS of placental efficiency in term infants, identifies genetic loci, and links PLE to monoaminergic pathways and placental tissue expression.

Microglial cannabinoid receptor type1 mediates social memory deficits produced by adolescent THC exposure and 16p11.2 duplication

This study shows that adolescent THC exposure causes microglial apoptosis in the mPFC, which is worsened by 16p11.2 duplication, leading to social memory deficits via microglial Cnr1.

The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder

This study identifies the miR-124-AMPAR pathway as a common mediator linking polygenic risks to shared behavioral changes in schizophrenia and bipolar disorder.

A single cell trajectory of human archetypal pluripotent stem cell differentiation to trophoblast stem cells reveals induction of endogenous BMP5/7 and GATA3 without transitioning through a naive state

This paper shows that primed human pluripotent stem cells can differentiate to trophoblast stem cells without becoming naive, using specific signaling conditions and revealing a transcriptional network involving BMP5/7 and GATA3.

Association of a lincRNA postmortem with suicide by violent means and in vivo with aggressive phenotypes

The paper replicates a postmortem association of LINC01268 with violent suicide and links it to in vivo aggression and prefrontal cortex function in living individuals.

Placental gene expression mediates the interaction between obstetrical history and genetic risk for schizophrenia

The paper shows that placental gene expression mediates the interaction between obstetrical history and genetic risk for schizophrenia, with ELCs enhancing PRS effects.