An integrated in silico-in vitro workflow for discovering high-affinity, selective antibodies to the KRAS(G12D)-MHC I complex
Sangphil Ahn, Tae-Sung Oh, Seonghyuk Suh, Jung Ho Jeon, Sangjoon Lah, Kyeongmin Ryu, Hyeonkyeong Kim, Eun Gyo Lee, Hyejin Lee, Joo Yeon Lee, Dongkyun Kim, Bo Mi Ku, WooRam Jung, Myung‐Ju Ahn, Jae Ung Jung, , Bo-Seong Jeong
The paper develops an in silico-in vitro workflow to generate high-affinity antibodies targeting the KRAS(G12D)-MHC I complex, achieving nanomolar affinity and specific T cell activation.
bioRxiv · Aug 31, 2025 · PreprintBiochemistry