Pro-endometriosis macrophage release of IL-33 is key for endometriosis pain and lesion formation
Victor Fattori, Fernanda Soares Rasquel-Oliveira, Soledad Ochoa, Eva Graf, María Victoria Bazzano, Thiha Aung, Mehmet Vural, Cynthia Kohl, María Emilia Solano, Matheus Deroco Veloso da Silva, Olivia K. Heintz, Stuart M. Brierley, Waldiceu Aparecido Verri Jr, Silke Haerteis, Joel Castro, , Michael S. Rogers
This study identifies IL-33 as a key mediator in endometriosis pain and lesion formation through neuroimmune communication involving CGRP and macrophages.
bioRxiv · Oct 20, 2025 · PreprintNeuroscience