FOS binding sites are a hub for the evolution of activity-dependent gene regulatory programs in human neurons
Ava C. Carter, Gabriel T. Koreman, Jillian E Petrocelli, Josephine E. Robb, Evan M. Bushinsky, Sara K. Trowbridge, David M. Kingsley, Christopher A. Walsh, Janet H. T. Song, Michael E. Greenberg
The paper identifies human-specific activity-dependent genes regulated by FOS-bound enhancers, showing their role in human brain development evolution.
bioRxiv · Mar 31, 2025 · PreprintEvolutionary Biology