RAF inhibitors activate the integrated stress response by direct activation of GCN2
Rebecca Gilley, Andrew M. Kidger, Graham W. Neill, Eve Morrison, Paul L. Severson, Dominic P. Byrne, Niall Steven Kenneth, Gideon E. Bollag, Chao Zhang, Taianá Maia de Oliveira, Patrick A. Eyers, Richard W. Bayliss, Glenn Robert Masson, Simon J. Cook
This study shows RAF inhibitors activate the integrated stress response via direct GCN2 activation, independent of ERK1/2, leading to ATF4 and CHOP expression.
Nature Communications · Nov 17, 2025Peer-reviewedBiochemistry