Simon J. Cook

This study shows that IKKα and IKKβ stabilize NEMO via kinase-independent scaffolding, preventing its proteasomal degradation and NF-κB signaling.

This study identifies DYRK1B as a regulator of processing body abundance through phosphoproteomics and functional assays.

This study shows that TCR-ligand affinity quantitatively modulates transcriptome remodelling in vivo, affecting cell division and interferon response.

The paper identifies NF-kappaB-dependent gene expression changes under hypoxia, showing its role in repression of hypoxia-downregulated genes and regulation of oxidative phosphorylation.

This study identifies how different KRAS G12 alleles alter glutamine metabolism and nitrogen recycling through FOXO1 regulation in colorectal cancer cells, revealing potential therapeutic targets.

This study shows RAF inhibitors activate the integrated stress response via direct GCN2 activation, independent of ERK1/2, leading to ATF4 and CHOP expression.

The paper shows ATP-competitive inhibitors paradoxically activate GCN2 through allosteric activation and autophosphorylation, suggesting alternative strategies for GCN2 inhibition.

The paper shows that DNA replication during MEK inhibition drives BRAF amplification and resistance in COLO205 cells, and that blocking cell cycle entry can suppress resistance.