Graham W. Neill

This study shows RAF inhibitors activate the integrated stress response via direct GCN2 activation, independent of ERK1/2, leading to ATF4 and CHOP expression.

This study shows heme binding to HRI causes structural changes that inhibit its autophosphorylation, affecting eIF2 kinase activity.

The paper shows ATP-competitive inhibitors paradoxically activate GCN2 through allosteric activation and autophosphorylation, suggesting alternative strategies for GCN2 inhibition.

The paper identifies and functionally validates dynamically accessible chromatin regions in response to IL-1 stimulation using ATAC-seq and CRISPR/Cas9.