N4-hydroxycytidine and inhibitors of dihydroorotate dehydrogenase synergistically suppress SARS-CoV-2 replication
Kim M. Stegmann, Antje Dickmanns, Natalie Heinen, Claudia Blaurock, Tim Karrasch, Angele Breithaupt, Robert Klopfleisch, Nadja Uhlig, Valentina Eberlein, Leila Issmail, Simon T. Herrmann, Amelie Schreieck, Evelyn Peelen, Hella Kohlhof, Alexander Riek, , Matthias Dobbelstein
This paper shows that combining N4-hydroxycytidine and DHODH inhibitors strongly reduces SARS-CoV-2 replication in cell cultures.
bioRxiv · Jun 28, 2021 · PreprintMolecular Biology