Dirk Görlich

The paper explores the sequence space of Xpo1-dependent NESs using high-throughput screening and identifies key residues critical for NES activity, revealing an affinity ceiling that explains natural NES limitations.

The paper discovers that sarcomeres divide along the myofibril tension axis during Drosophila muscle development to add new sarcomeres while maintaining mechanical integrity.

The paper identifies molecular determinants enabling HIV capsid passage through NPCs by analyzing surface amino acid composition and FG repeat interactions.

The paper identifies a titin-dependent biomechanical feedback mechanism that adjusts sarcomere structure to meet the functional demands of different insect muscle types.

The paper develops a nanobody toolbox to study the localization and dynamics of Drosophila titin homologs in muscle sarcomeres, revealing structural insights and demonstrating nanobodies' utility in vivo.

The paper uses nanobodies and DNA-PAINT to show that Drosophila titin homologs Sallimus and Projectin are staggered in flight muscle sarcomeres.

This paper shows that combining N4-hydroxycytidine and DHODH inhibitors strongly reduces SARS-CoV-2 replication in cell cultures.

This paper shows that methotrexate inhibits SARS-CoV-2 replication in cell cultures and synergizes with remdesivir, suggesting potential for repurposing MTX in treating COVID-19.