Inhibition of sensory neuron driven acute, inflammatory, and neuropathic pain using a humanised chemogenetic system
Jimena Pérez-Sánchez, Steven J. Middleton, Luke A. Pattison, Helen Hilton, Mosab Ali Awadelkareem, Sana R. Zuberi, Maria B. Renke, Huimin Hu, Xun Yang, Alex J. Clark, Ewan St, John Smith, David Bennett
This study demonstrates the efficacy of a humanised chemogenetic system in silencing sensory neuron hyperexcitability and reducing pain in both mouse and human models.
bioRxiv · Mar 21, 2023 · PreprintNeuroscience