Author

Steven J. Middleton

University of OxfordORCID 0000-0002-0708-7335Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Steven J. Middleton1 paper · Max Delbrück Center

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

David BennettiD· 3 shared Jimena Pérez-SáncheziD· 3 shared Sana R. ZuberiiD· 2 shared Adham FarahiD· 1 shared Alex J. ClarkiD· 1 shared Blair Hamilton SmithiD· 1 shared Evangelia SemizoglouiD· 1 shared Ewan St· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersNeuroscience

David BennettORCID

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3 papers

Recent·Most cited

Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter.

Steven J. Middleton, Sigurbjörn Markússon, Mikael Åkerlund, Justin C. Deme, Mandy Tseng, Wenqianglong Li, Sana R. Zuberi, Gabriel Kuteyi, Peter Sarkies, Georgios Baskozos, Jimena Pérez-Sánchez, Harry L. Hébert, Sylvanus Toikumo, Adham Farah, Susan Maxwell, , David Bennett

The paper identifies SLC45A4 as a pain-related gene encoding a neuronal polyamine transporter through GWAS and functional studies.

bioRxiv · Sep 25, 2024 · PreprintNeuroscience

Characterising the stimulus-response function of mouse C-low threshold mechanoreceptors to mechanical stimuli in vivo

Evangelia Semizoglou, Laure Lo Re, Steven J. Middleton, Jimena Pérez-Sánchez, Tommaso Tufarelli, David Bennett, Kim I. Chisholm

This study uses in vivo calcium imaging to characterize the stimulus-response function of mouse C-low threshold mechanoreceptors to mechanical stimuli.

bioRxiv · Mar 18, 2024 · PreprintNeuroscience

Inhibition of sensory neuron driven acute, inflammatory, and neuropathic pain using a humanised chemogenetic system

Jimena Pérez-Sánchez, Steven J. Middleton, Luke A. Pattison, Helen Hilton, Mosab Ali Awadelkareem, Sana R. Zuberi, Maria B. Renke, Huimin Hu, Xun Yang, Alex J. Clark, Ewan St, John Smith, David Bennett

This study demonstrates the efficacy of a humanised chemogenetic system in silencing sensory neuron hyperexcitability and reducing pain in both mouse and human models.

bioRxiv · Mar 21, 2023 · PreprintNeuroscience