Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli
S. Zheng, L.-T. Sham, F. A. Rubino, K. Brock, W. P. Robins, J. J. Mekalanos, D. S. Marks, T. G. Bernhardt, A. C. Kruse
The paper reports the crystal structure of MurJ from E. coli, performs mutagenesis to map functional sites, and identifies co-evolved interactions supporting a rocker-switch model for lipid II transport.
bioRxiv · Feb 19, 2018Biochemistry