Author

L.-T. Sham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:structural biology· 1

Frequent Co-Authors

A. C. Kruse· 1 shared D. I. Roper· 1 shared D. S. Marks· 1 shared F. A. Rubino· 1 shared J. A. Hermoso· 1 shared J. J. Mekalanos· 1 shared J. Li· 1 shared J. Shi· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

A. C. Kruse

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2 papers

Recent·Most cited

Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division

J. Li, Y. He, X. Xu, M. Alcorlo, J. Shi, S. Naskar, N. Briggs, D. I. Roper, J. A. Hermoso, L.-T. Sham, M. Luo

This study presents structural and biochemical analysis of E. coli FtsEX complex, revealing ATP's role in stabilization and EnvC-mediated activation of PG hydrolysis.

bioRxiv · Jan 16, 2024 · PreprintMicrobiology

Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli

S. Zheng, L.-T. Sham, F. A. Rubino, K. Brock, W. P. Robins, J. J. Mekalanos, D. S. Marks, T. G. Bernhardt, A. C. Kruse

The paper reports the crystal structure of MurJ from E. coli, performs mutagenesis to map functional sites, and identifies co-evolved interactions supporting a rocker-switch model for lipid II transport.

bioRxiv · Feb 19, 2018Biochemistry