Author

J. J. Mekalanos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:DNA methylation· 1 Organism:E. coli· 1

Frequent Co-Authors

W. P. Robins· 3 shared A. C. Kruse· 1 shared A. Hsiao· 1 shared A. T. Whiteley· 1 shared B. Bao· 1 shared B. Lowey· 1 shared B. T. Meader· 1 shared C. Benoist· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

W. P. Robins

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Microbiome induced complement synthesized in the gut protects against enteric infections

M. Wu, W. Zheng, X. Song, B. Bao, Y. Wang, D. Ramanan, D. Yang, R. Liu, J. C. Macbeth, E. A. Do, W. A. Andrade, T. Yang, H.-S. Cho, F. S. Gazzaniga, M. Ilves, , D. L. Kasper

The paper shows gut microbiota regulate complement component 3 (C3) production in humans and mice, with intestinal C3 levels correlating with protection against enteric infections.

bioRxiv · Feb 2, 2023 · PreprintImmunology

Cell density-dependent death triggered by viral palindromic DNA sequences

W. P. Robins, B. T. Meader, J. Toska, J. J. Mekalanos

The paper identifies palindromic DNA sequences that trigger cell-density dependent death in Vibrio cholerae via the DdmABC/PriA system during DNA replication stress.

bioRxiv · Nov 18, 2022 · PreprintMicrobiology

Covariance predicts conserved protein residue interactions important to the emergence and continued evolution of SARS-CoV-2 as a human pathogen

W. P. Robins, J. J. Mekalanos

The paper identifies conserved protein residue interactions in SARS-CoV-2 related coronaviruses that correlate with their emergence and evolution as human pathogens.

bioRxiv · Jan 13, 2022Microbiology

Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity

R. K. Lau, Q. Ye, L. Patel, K. R. Berg, I. T. Mathews, J. D. Watrous, A. T. Whiteley, B. Lowey, J. J. Mekalanos, P. J. Kranzusch, M. Jain, K. Corbett

The paper characterizes NucC, a bacterial endonuclease activated by cyclic tri-AMP to mediate bacteriophage immunity through DNA cleavage or cell death.

bioRxiv · Jul 7, 2019Biochemistry

Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli

S. Zheng, L.-T. Sham, F. A. Rubino, K. Brock, W. P. Robins, J. J. Mekalanos, D. S. Marks, T. G. Bernhardt, A. C. Kruse

The paper reports the crystal structure of MurJ from E. coli, performs mutagenesis to map functional sites, and identifies co-evolved interactions supporting a rocker-switch model for lipid II transport.

bioRxiv · Feb 19, 2018Biochemistry