Recombinant rotaviruses rescued by reverse genetics reveal the role of NSP5 hyperphosphorylation in the assembly of viral factories
G. Papa, L. Venditti, F. Arnoldi, E. M. Schraner, C. Potgieter, A. Borodavka, C. Eichwald, O. R. Burrone
This study uses reverse genetics to generate recombinant rotaviruses with NSP5 mutations, revealing that NSP5 hyperphosphorylation is essential for viroplasm assembly and viral replication.
bioRxiv · Jul 8, 2019Microbiology