G. Papa

Recruitment of TRiC chaperonin in rotavirus viroplasms directly associates with virus replication.

This study identifies TRiC chaperonin as a component of rotavirus viroplasms essential for dsRNA synthesis and virus replication.

Rotavirus spike protein VP4 mediates viroplasm assembly by association to actin filaments

This study shows that rotavirus VP4 interacts with actin filaments to facilitate viroplasm assembly, using a recombinant virus with a modified VP4 to demonstrate the role of this interaction.

SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

This study investigates the immune escape, infectivity, and cell-cell fusion properties of SARS-CoV-2 Omicron BA.1 compared to Delta, showing higher ACE2 affinity and antibody evasion but similar antiviral drug efficacy.

A recombinant rotavirus harboring a spike protein with a heterologous peptide reveals a novel role of VP4 in viroplasm stability

This paper engineers a recombinant rotavirus with a VP4-BAP tag, showing VP4's role in viroplasm stability and replication fitness.

SARS-CoV-2 B.1.617.2 Delta variant replication, sensitivity to neutralising antibodies and vaccine breakthrough

This study evaluates the replication, antibody sensitivity, and vaccine efficacy of the SARS-CoV-2 B.1.617.2 Delta variant compared to other variants and vaccine-elicited immunity.

Principles of RNA recruitment to viral ribonucleoprotein condensates in a segmented dsRNA virus

The paper investigates how rotavirus transcripts are recruited into viroplasms, showing that RNA enrichment depends on conserved terminal regions and varies among transcripts.

Rotavirus Replication Factories Are Complex Ribonucleoprotein Condensates

This study shows rotavirus replication factories are RNA-protein condensates formed by phase separation, with unique features that could be targeted for antiviral therapies.

Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion H69/V70

This paper identifies a recurrent SARS-CoV-2 Spike deletion (H69/V70) that increases infectivity and compensates for RBD mutations, suggesting it may facilitate immune escape and variant emergence.

Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation

This study identifies cytoplasmic tail sequences in SARS-CoV-2 Spike that facilitate surface expression and syncytia formation by interacting with cellular factors like COPI, COPII, and ERM proteins.

Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion

CRISPR-Csy4-mediated editing of rotavirus double-stranded RNA genome

This study uses CRISPR-Csy4 to edit rotavirus dsRNA genome, enabling labeling of secondary transcription products and insights into viral replication.

Recombinant rotaviruses rescued by reverse genetics reveal the role of NSP5 hyperphosphorylation in the assembly of viral factories

This study uses reverse genetics to generate recombinant rotaviruses with NSP5 mutations, revealing that NSP5 hyperphosphorylation is essential for viroplasm assembly and viral replication.