Intra-granuloma accumulation and inflammatory differentiation of neutrophils underlie mycobacterial ESX-1-mediated immunopathology
J. Lienard, K. Munke, L. Wulff, C. Da Silva, J. Vandamme, K. Laschanzky, T. Joeris, W. Agace, F. Carlsson
This study identifies ESX-1-mediated neutrophil accumulation and inflammatory differentiation as drivers of mycobacterial immunopathology, with monocytes suppressing this process via iNOS.
bioRxiv · Jan 19, 2022 · PreprintMicrobiology