Author

F. E. Lumb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1 Approach:machine learning (classical)· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Tarafdar· 3 shared M. A. Pineda· 3 shared M. M. Harnett· 3 shared W. Harnett· 3 shared J. Crowe· 2 shared J. Doonan· 2 shared P. A. Hoskisson· 2 shared A. M. Khan· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersImmunology

A. Tarafdar

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ES-62 suppression of arthritis reflects epigenetic rewiring of synovial fibroblasts to a joint-protective phenotype

M. Corbet, M. A. Pineda, K. Yang, A. Tarafdar, S. McGrath, R. Nakagawa, F. E. Lumb, W. Harnett, M. M. Harnett

This study shows ES-62 induces an epigenetic protective phenotype in synovial fibroblasts by remodelling their DNA methylome, potentially offering new therapeutic strategies for rheumatoid arthritis.

bioRxiv · Oct 8, 2020 · PreprintPathology

Parasitic worm-derived ES-62 promotes health- and life-span in high calorie diet-fed mice

J. Crowe, F. E. Lumb, J. Doonan, M. Broussard, A. Tarafdar, M. A. Pineda, C. Landabaso, L. Mulvey, P. A. Hoskisson, S. Babayan, C. Selman, W. Harnett, M. M. Harnett

ES-62, a parasitic worm-derived immunomodulator, improves healthspan and extends lifespan in male mice fed a high-calorie diet.

bioRxiv · Jun 22, 2019 · PreprintImmunology

The parasitic worm product ES-62 normalises the gut microbiota/bone marrow axis in inflammatory arthritis

J. Doonan, A. Tarafdar, M. A. Pineda, F. E. Lumb, J. Crowe, A. M. Khan, P. A. Hoskisson, M. M. Harnett, W. Harnett

This study shows that the parasitic worm product ES-62 reduces joint inflammation in arthritis by normalising gut microbiota and preserving intestinal barrier integrity without requiring live helminth infection.

bioRxiv · Nov 2, 2018Immunology