Author

F. J. Sorrell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. A. Ahmed· 1 shared A. A. Wegener· 1 shared A. Chaikuad· 1 shared A. N. Kettenbach· 1 shared E.-M. Leibrock· 1 shared F. Miranda· 1 shared H. J. Bailey· 1 shared I. Dikic· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. A. Ahmed

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2 papers

Recent·Most cited

Engineering CRBN for rapid identification of next generation binders

H. J. Bailey, J. Eisert, J. Vollrath, E.-M. Leibrock, I. Kondratov, T. Matviyuk, N. Tolmachova, J. D. Langer, A. A. Wegener, F. J. Sorrell, I. Dikic

This paper introduces a new CRBN construct for efficient binder discovery, showing it outperforms existing constructs in binding and production, and applies it to identify potent CRBN binders from a large compound library.

bioRxiv · Jan 18, 2024 · PreprintBiophysics

STK32A is a dual-specificity AGC kinase with a preference for acidic substrates

F. J. Sorrell, F. Miranda, K. R. Abdul Azeez, A. Chaikuad, A. N. Kettenbach, S. Gerber, S. Knapp, A. A. Ahmed, J. Elkins

This study identifies STK32A as a dual-specificity AGC kinase preferring acidic substrates, revealing structural and evolutionary features supporting its substrate specificity.

bioRxiv · Mar 4, 2020 · PreprintBiochemistry