Author

J. Vollrath

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

B. A. Burleigh· 2 shared J. X. Wang· 2 shared A. A. Wegener· 1 shared E.-M. Leibrock· 1 shared F. J. Sorrell· 1 shared H. J. Bailey· 1 shared I. Dikic· 1 shared I. Kondratov· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

B. A. Burleigh

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Engineering CRBN for rapid identification of next generation binders

H. J. Bailey, J. Eisert, J. Vollrath, E.-M. Leibrock, I. Kondratov, T. Matviyuk, N. Tolmachova, J. D. Langer, A. A. Wegener, F. J. Sorrell, I. Dikic

This paper introduces a new CRBN construct for efficient binder discovery, showing it outperforms existing constructs in binding and production, and applies it to identify potent CRBN binders from a large compound library.

bioRxiv · Jan 18, 2024 · PreprintBiophysics

Endogenous sterol synthesis is dispensable for Trypanosoma cruzi epimastigote growth but not stress tolerance

P. Dumoulin, J. Vollrath, M. Won, J. X. Wang, B. A. Burleigh

This study shows that CYP51 is not essential for T. cruzi epimastigote growth but is required for stress tolerance, as its disruption leads to sterol auxotrophy and sensitivity to elevated temperature.

bioRxiv · May 3, 2022Microbiology

Glutamine metabolism modulates azole susceptibility in Trypanosoma cruzi amastigotes

P. C. Dumoulin, J. Vollrath, J. X. Wang, B. A. BURLEIGH

This study shows that glutamine metabolism affects azole susceptibility in Trypanosoma cruzi amastigotes by influencing sterol biosynthesis and metabolic intermediates.

bioRxiv · Jun 19, 2020Microbiology